2P54

a crystal structure of PPAR alpha bound with SRC1 peptide and GW735

2P54 の概要

• エントリーDOI: 10.2210/pdb2p54/pdb
• 分子名称: Peroxisome proliferator-activated receptor alpha, Nuclear receptor coactivator 1, 2-METHYL-2-(4-{[({4-METHYL-2-[4-(TRIFLUOROMETHYL)PHENYL]-1,3-THIAZOL-5-YL}CARBONYL)AMINO]METHYL}PHENOXY)PROPANOIC ACID, ... (4 entities in total)
• 機能のキーワード: ppar alpha gw735 src1 agonist hdlc, transcription
• 由来する生物種: Homo sapiens (human); 詳細
• 細胞内の位置: Nucleus: Q07869; Nucleus (By similarity): Q15788
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 32267.71

構造登録者

Xu, R.X.,Xu, H.E.,Sierra, M.L.,Montana, V.G.,Lambert, M.H.,Pianetti, P.M. (登録日: 2007-03-14, 公開日: 2007-04-24, 最終更新日: 2024-04-03)

• 主引用文献: Sierra, M.L.,Beneton, V.,Boullay, A.B.,Boyer, T.,Brewster, A.,Donche, F.,Forest, M.C.,Fouchet, M.H.,Gellibert, F.J.,Grillot, D.A.,Lambert, M.H.,Laroze, A.,Grumelec, C.L.,Linget, J.M.,Montana, V.G.,Nguyen, V.L.,Nicodeme, E.,Patel, V.,Penfornis, A.,Pineau, O.,Pohin, D.,Potvain, F.,Paulain, G.,Ruault, C.B.,Saunders, M.,Toum, J.,Xu, H.E.,Xu, R.X.,Pianetti, P.M.; Substituted 2-[(4-Aminomethyl)phenoxy]-2-methylpropionic Acid PPAR Agonists. 1.Discovery of a Novel Series of Potent HDLc Raising Agents.; J.Med.Chem., 50:685-695, 2007; PubMed: 17243659; DOI: 10.1021/jm058056x

実験手法

X-RAY DIFFRACTION (1.79 Å)