2P3G
Crystal structure of a pyrrolopyridine inhibitor bound to MAPKAP Kinase-2
Summary for 2P3G
Entry DOI | 10.2210/pdb2p3g/pdb |
Related | 1KWP 1NXK 1NY3 2ONL |
Descriptor | MAP kinase-activated protein kinase 2, 2-[2-(2-FLUOROPHENYL)PYRIDIN-4-YL]-1,5,6,7-TETRAHYDRO-4H-PYRROLO[3,2-C]PYRIDIN-4-ONE (2 entities in total) |
Functional Keywords | kinase domain, atp-binding, serine/threonine kinase, map kinases, mk-2, mk2, transferase |
Biological source | Homo sapiens (human) |
Cellular location | Cytoplasm : P49137 |
Total number of polymer chains | 1 |
Total formula weight | 38205.07 |
Authors | Kurumbail, R.G.,Caspers, N. (deposition date: 2007-03-08, release date: 2007-06-12, Last modification date: 2024-04-03) |
Primary citation | Anderson, D.R.,Meyers, M.J.,Vernier, W.F.,Mahoney, M.W.,Kurumbail, R.G.,Caspers, N.,Poda, G.I.,Schindler, J.F.,Reitz, D.B.,Mourey, R.J. Pyrrolopyridine Inhibitors of Mitogen-Activated Protein Kinase-Activated Protein Kinase 2 (MK-2). J.Med.Chem., 50:2647-2654, 2007 Cited by PubMed: 17480064DOI: 10.1021/jm0611004 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (3.8 Å) |
Structure validation
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