2P16

Factor Xa in Complex with the Inhibitor APIXABAN (BMS-562247) AKA 1-(4-METHOXYPHENYL)-7-OXO-6-(4-(2-OXO-1-PIPERIDINYL)PHENYL)-4,5,6,7-TETRAHYDRO-1H-PYRAZOLO[3, 4-C]PYRIDINE-3-CARBOXAMIDE

2P16 の概要

• エントリーDOI: 10.2210/pdb2p16/pdb
• 分子名称: Coagulation factor X (EC 3.4.21.6) (Stuart factor) (Stuart-Prower factor), CALCIUM ION, 1-(4-METHOXYPHENYL)-7-OXO-6-[4-(2-OXOPIPERIDIN-1-YL)PHENYL]-4,5,6,7-TETRAHYDRO-1H-PYRAZOLO[3,4-C]PYRIDINE-3-CARBOXAMIDE, ... (5 entities in total)
• 機能のキーワード: glycoprotein, hydrolase, serine protease, plasma, blood coagulation factor, protein inhibitor complex, calcium-binding
• 由来する生物種: Homo sapiens (human); 詳細
• 細胞内の位置: Secreted: P00742 P00742
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 32535.91

構造登録者

Alexander, R. (登録日: 2007-03-02, 公開日: 2007-10-16, 最終更新日: 2023-08-30)

• 主引用文献: Pinto, D.J.,Orwat, M.J.,Koch, S.,Rossi, K.A.,Alexander, R.S.,Smallwood, A.,Wong, P.C.,Rendina, A.R.,Luettgen, J.M.,Knabb, R.M.,He, K.,Xin, B.,Wexler, R.R.,Lam, P.Y.; Discovery of 1-(4-Methoxyphenyl)-7-oxo-6-(4-(2-oxopiperidin-1-yl)phenyl)-4,5,6,7-tetrahydro- 1H-pyrazolo[3,4-c]pyridine-3-carboxamide (Apixaban, BMS-562247), a Highly Potent, Selective, Efficacious, and Orally Bioavailable Inhibitor of Blood Coagulation Factor Xa.; J.Med.Chem., 50:5339-5356, 2007; PubMed: 17914785; DOI: 10.1021/jm070245n

実験手法

X-RAY DIFFRACTION (2.3 Å)