2OZL

Human pyruvate dehydrogenase S264E variant

2OZL の概要

• エントリーDOI: 10.2210/pdb2ozl/pdb
• 分子名称: Pyruvate dehydrogenase E1 component alpha subunit, somatic form, Pyruvate dehydrogenase E1 component subunit beta, MAGNESIUM ION, ... (6 entities in total)
• 機能のキーワード: pyruvate_dehydrogenase_complex; human; e1; multienzyme_complex_component; thiamine_pyrophosphate; thiamin_diphosphate; heterotetrameric; lipoyl_substrate; pyruvate; dihydrolipoamide_acetyltransferase; dihydrolipoamide_dehydrogenase;, oxidoreductase
• 由来する生物種: Homo sapiens (human); 詳細
• 細胞内の位置: Mitochondrion matrix: P08559 P11177
• タンパク質・核酸の鎖数: 4
• 化学式量合計: 157184.15

構造登録者

Ciszak, E.M.,Dominiak, P.M.,Patel, M.S.,Korotchkina, L.G. (登録日: 2007-02-26, 公開日: 2007-05-22, 最終更新日: 2023-08-30)

• 主引用文献: Seifert, F.,Ciszak, E.M.,Korotchkina, L.G.,Golbik, R.,Spinka, M.,Dominiak, P.M.,Sidhu, S.,Brauer, J.,Patel, M.S.,Tittmann, K.; Phosphorylation of Serine 264 Impedes Active Site Accessibility in the E1 Component of the Human Pyruvate Dehydrogenase Multienzyme Complex; Biochemistry, 46:6277-6287, 2007; PubMed: 17474719; DOI: 10.1021/bi700083z

実験手法

X-RAY DIFFRACTION (1.9 Å)