2OYE

Indomethacin-(R)-alpha-ethyl-ethanolamide bound to Cyclooxygenase-1

Summary for 2OYE

Entry DOI	10.2210/pdb2oye/pdb
Related	1CQE 1EQE 1PGF 1PGG
Descriptor	Prostaglandin G/H synthase 1, 2-acetamido-2-deoxy-alpha-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, beta-D-mannopyranose-(1-6)-beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... (9 entities in total)
Functional Keywords	cox, pghs, indomethacin, nsaid, heme, oxidoreductase
Biological source	Ovis aries (sheep)
Total number of polymer chains	1
Total formula weight	72267.83
Authors	Harman, C.A.,Garavito, R.M. (deposition date: 2007-02-21, release date: 2007-07-24, Last modification date: 2020-07-29)
Primary citation	Harman, C.A.,Turman, M.V.,Kozak, K.R.,Marnett, L.J.,Smith, W.L.,Garavito, R.M. Structural basis of enantioselective inhibition of cyclooxygenase-1 by S-alpha-substituted indomethacin ethanolamides. J.Biol.Chem., 282:28096-28105, 2007 Cited by PubMed: 17656360 DOI: 10.1074/jbc.M701335200 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.85 Å)

Structure validation