2OXQ

Structure of the UbcH5 :CHIP U-box complex

2OXQ の概要

• エントリーDOI: 10.2210/pdb2oxq/pdb
• 分子名称: Ubiquitin-conjugating enzyme E2D 1, STIP1 homology and U-Box containing protein 1, CHLORIDE ION, ... (4 entities in total)
• 機能のキーワード: protein-protein complex, ligase
• 由来する生物種: Danio rerio (zebrafish); 詳細
• タンパク質・核酸の鎖数: 4
• 化学式量合計: 52338.12

構造登録者

Xu, Z.,Nix, J.C.,Devlin, K.I.,Misra, S. (登録日: 2007-02-20, 公開日: 2008-02-19, 最終更新日: 2023-08-30)

主引用文献

Xu, Z.,Kohli, E.,Devlin, K.I.,Bold, M.,Nix, J.C.,Misra, S.
Interactions between the quality control ubiquitin ligase CHIP and ubiquitin conjugating enzymes.
Bmc Struct.Biol., 8:26-26, 2008

PubMed Abstract: Ubiquitin (E3) ligases interact with specific ubiquitin conjugating (E2) enzymes to ubiquitinate particular substrate proteins. As the combination of E2 and E3 dictates the type and biological consequence of ubiquitination, it is important to understand the basis of specificity in E2:E3 interactions. The E3 ligase CHIP interacts with Hsp70 and Hsp90 and ubiquitinates client proteins that are chaperoned by these heat shock proteins. CHIP interacts with two types of E2 enzymes, UbcH5 and Ubc13-Uev1a. It is unclear, however, why CHIP binds these E2 enzymes rather than others, and whether CHIP interacts preferentially with UbcH5 or Ubc13-Uev1a, which form different types of polyubiquitin chains.

PubMed: 18485199
DOI: 10.1186/1472-6807-8-26

実験手法

X-RAY DIFFRACTION (2.9 Å)