2OSL

Crystal structure of Rituximab Fab in complex with an epitope peptide

2OSL の概要

分子名称light chain of the Rituximab Fab fragment, heavy chain of the Rituximab Fab fragment, B-lymphocyte antigen CD20, ... (4 entities in total)
機能のキーワードfab-peptide complex, rituximab, chimeric antibody, immune system
由来する生物種Homo sapiens, Mus musculus (human, house mouse)
詳細
細胞内の位置Cell membrane ; Multi-pass membrane protein  P11836
ポリマー鎖数6
分子量合計99328.43
構造登録者
Du, J.,Zhong, C.,Ding, J. (登録日: 2007-02-06, 公開日: 2007-04-10, 最終更新日: 2017-10-18)
主引用文献
Du, J.,Wang, H.,Zhong, C.,Peng, B.,Zhang, M.,Li, B.,Huo, S.,Guo, Y.,Ding, J.
Structural basis for recognition of CD20 by therapeutic antibody Rituximab
J.Biol.Chem., 282:15073-15080, 2007
PubMed: 17395584 (主引用文献が同じPDBエントリー)
DOI: 10.1074/jbc.M701654200
MImport into Mendeley
実験手法
X-RAY DIFFRACTION (2.6 Å)
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構造検証レポート

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers0.254121.3%13.1%2.7%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution
検証レポート(詳細版)をダウンロード