2OS2
Crystal structure of JMJD2A complexed with histone H3 peptide trimethylated at Lys36
Summary for 2OS2
Entry DOI | 10.2210/pdb2os2/pdb |
Related | 2OQ6 2OQ7 2OT7 2OX0 |
Descriptor | JmjC domain-containing histone demethylation protein 3A, histone 3 peptide, NICKEL (II) ION, ... (6 entities in total) |
Functional Keywords | fe, double-stranded beta helix, demethylase, oxygenase, structural genomics, structural genomics consortium, sgc, oxidoreductase |
Biological source | Homo sapiens (human) More |
Cellular location | Nucleus: O75164 |
Total number of polymer chains | 4 |
Total formula weight | 91745.92 |
Authors | Kavanagh, K.L.,Ng, S.S.,Pilka, E.,McDonough, M.A.,Savitsky, P.,von Delft, F.,Arrowsmith, C.H.,Weigelt, J.,Edwards, A.,Sundstrom, M.,Schofield, C.J.,Oppermann, U.,Structural Genomics Consortium (SGC) (deposition date: 2007-02-05, release date: 2007-03-13, Last modification date: 2023-08-30) |
Primary citation | Ng, S.S.,Kavanagh, K.L.,McDonough, M.A.,Butler, D.,Pilka, E.S.,Lienard, B.M.,Bray, J.E.,Savitsky, P.,Gileadi, O.,von Delft, F.,Rose, N.R.,Offer, J.,Scheinost, J.C.,Borowski, T.,Sundstrom, M.,Schofield, C.J.,Oppermann, U. Crystal structures of histone demethylase JMJD2A reveal basis for substrate specificity. Nature, 448:87-91, 2007 Cited by PubMed: 17589501DOI: 10.1038/nature05971 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.3 Å) |
Structure validation
Download full validation report