2ORQ

Murine Inducible Nitric Oxide Synthase Oxygenase Domain (DELTA 114) 4-(imidazol-1-yl)phenol and piperonylamine Complex

2ORQ の概要

• エントリーDOI: 10.2210/pdb2orq/pdb
• 関連するPDBエントリー: 1DD7 1NOC 1NOD 1NOS 1NSI 2NOS 2ORO 2ORP 2ORR 2ORS 2ORT
• 分子名称: Nitric oxide synthase, inducible, PROTOPORPHYRIN IX CONTAINING FE, 4-(1H-IMIDAZOL-1-YL)PHENOL, ... (5 entities in total)
• 機能のキーワード: nitric oxide, l-arginine monooxygenase, heme, dimerization, inhibitor, nos, oxidoreductase
• 由来する生物種: Mus musculus (house mouse)
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 46198.20

構造登録者

Adler, M.,Whitlow, M. (登録日: 2007-02-04, 公開日: 2007-04-17, 最終更新日: 2024-02-21)

• 主引用文献: Davey, D.D.,Adler, M.,Arnaia, D.,Eagen, K.,Erickson, S.,Guilford, W.,Kenrick, M.,Morrissey, M.M.,Ohimeyer, M.,Pan, G.,Paradkar, V.M.,Parkinson, J.,Polokoff, M.,Salonz, K.,Santos, C.,Subramanyam, B.,Vergona, R.,Wei, R.G.,Whitlow, M.,Ye, B.,Zhao, Z.S.,Devlin, J.J.,Phillips, G.; Design, Synthesis, and Activity of 2-Imidazol-1-ylpyrimidine Derived Inducible Nitric Oxide Synthase Dimerization Inhibitors; J.Med.Chem., 50:1146-1157, 2007; PubMed: 17315988; DOI: 10.1021/jm061319i

実験手法

X-RAY DIFFRACTION (2.1 Å)