2OQ1

Tandem SH2 domains of ZAP-70 with 19-mer zeta1 peptide

2OQ1 の概要

• エントリーDOI: 10.2210/pdb2oq1/pdb
• 分子名称: Tyrosine-protein kinase ZAP-70, T-cell surface glycoprotein CD3 zeta chain, LEAD (II) ION, ... (4 entities in total)
• 機能のキーワード: tandem sh2 domains, zap-70, tyrosine kinase, transferase
• 由来する生物種: Homo sapiens (human); 詳細
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 31629.33

構造登録者

Hatada, M.H.,Laird, E.R.,Green, J.,Morgenstern, J.,Ram, M.K. (登録日: 2007-01-30, 公開日: 2007-03-06, 最終更新日: 2024-11-06)

主引用文献

Hatada, M.H.,Lu, X.,Laird, E.R.,Green, J.,Morgenstern, J.P.,Lou, M.,Marr, C.,Phillips, T.B.,Ram, M.K.,Theriault, K.
Molecular basis for the interaction of ZAP-70 with the T-cell receptor
Nature, 377:32-38, 1995

PubMed Abstract: The crystal structure of the tandem SH2 domains of human ZAP-70 in complex with a peptide derived from the zeta-subunit of the T-cell receptor reveals an unanticipated interaction between the two domains. A coiled coil of alpha-helices connects the two SH2 domains, producing an interface that constitutes one of the two critical phosphotyrosine binding sites. These and other unique features provide the molecular basis for highly selective association of ZAP-70 with the T-cell receptor.

PubMed: 7659156
DOI: 10.1038/377032a0

実験手法

X-RAY DIFFRACTION (1.9 Å)