2OPQ

Crystal Structure of L100I Mutant HIV-1 Reverse Transcriptase in Complex with GW420867X.

2OPQ の概要

• エントリーDOI: 10.2210/pdb2opq/pdb
• 分子名称: Reverse transcriptase/ribonuclease H, p51 RT, PHOSPHATE ION, ... (5 entities in total)
• 機能のキーワード: hiv-1 reverse transcriptase, aids, nnrti, gw420867x, drug resistance, transferase
• 由来する生物種: HIV-1 M:B_HXB2R; 詳細
• 細胞内の位置: Matrix protein p17: Virion . Capsid protein p24: Virion . Nucleocapsid protein p7: Virion . Reverse transcriptase/ribonuclease H: Virion . Integrase: Virion : P04585 P04585
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 111985.17

構造登録者

Ren, J.,Nichols, C.E.,Chamberlain, P.P.,Weaver, K.L.,Short, S.A.,Chan, J.H.,Kleim, J.,Stammers, D.K. (登録日: 2007-01-30, 公開日: 2007-05-22, 最終更新日: 2023-12-27)

• 主引用文献: Ren, J.,Nichols, C.E.,Chamberlain, P.P.,Weaver, K.L.,Short, S.A.,Chan, J.H.,Kleim, J.P.,Stammers, D.K.; Relationship of Potency and Resilience to Drug Resistant Mutations for GW420867X Revealed by Crystal Structures of Inhibitor Complexes for Wild-Type, Leu100Ile, Lys101Glu, and Tyr188Cys Mutant HIV-1 Reverse Transcriptases.; J.Med.Chem., 50:2301-2309, 2007; PubMed: 17441703; DOI: 10.1021/jm061117m

実験手法

X-RAY DIFFRACTION (2.8 Å)