2OPB

Structure of K57A hPNMT with inhibitor 3-fluoromethyl-7-thiomorpholinosulfonamide-THIQ and AdoHcy

Summary for 2OPB

• Entry DOI: 10.2210/pdb2opb/pdb
• Related: 1HNN 2G8N
• Descriptor: Phenylethanolamine N-methyltransferase, (3R)-3-(FLUOROMETHYL)-7-(THIOMORPHOLIN-4-YLSULFONYL)-1,2,3,4-TETRAHYDROISOQUINOLINE, S-ADENOSYL-L-HOMOCYSTEINE, ... (5 entities in total)
• Functional Keywords: methyltransferase, transferase
• Biological source: Homo sapiens (human)
• Total number of polymer chains: 2
• Total formula weight: 65100.40

Authors

Drinkwater, N.,Martin, J.L. (deposition date: 2007-01-28, release date: 2007-10-09, Last modification date: 2023-08-30)

• Primary citation: Gee, C.L.,Drinkwater, N.,Tyndall, J.D.,Grunewald, G.L.,Wu, Q.,McLeish, M.J.,Martin, J.L.; Enzyme Adaptation to Inhibitor Binding: A Cryptic Binding Site in Phenylethanolamine N-Methyltransferase.; J.Med.Chem., 50:4845-4853, 2007; PubMed: 17845018; DOI: 10.1021/jm0703385

Experimental method

X-RAY DIFFRACTION (2.8 Å)