2OOH
Crystal Structure of MIF bound to a Novel Inhibitor, OXIM-11
Summary for 2OOH
Entry DOI | 10.2210/pdb2ooh/pdb |
Related | 2OOW 2OOZ |
Descriptor | Macrophage migration inhibitory factor, SULFATE ION, 4-HYDROXYBENZALDEHYDE O-(CYCLOHEXYLCARBONYL)OXIME, ... (5 entities in total) |
Functional Keywords | alternative ligand-binding modes, isomerase |
Biological source | Homo sapiens (human) |
Cellular location | Secreted : P14174 |
Total number of polymer chains | 3 |
Total formula weight | 38512.44 |
Authors | Crichlow, G.V.,Al-Abed, Y.,Lolis, E. (deposition date: 2007-01-25, release date: 2007-06-05, Last modification date: 2023-08-30) |
Primary citation | Crichlow, G.V.,Cheng, K.F.,Dabideen, D.,Ochani, M.,Aljabari, B.,Pavlov, V.A.,Miller, E.J.,Lolis, E.,Al-Abed, Y. Alternative chemical modifications reverse the binding orientation of a pharmacophore scaffold in the active site of macrophage migration inhibitory factor. J.Biol.Chem., 282:23089-23095, 2007 Cited by PubMed: 17526494DOI: 10.1074/jbc.M701825200 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.85 Å) |
Structure validation
Download full validation report