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2OOH

Crystal Structure of MIF bound to a Novel Inhibitor, OXIM-11

Summary for 2OOH
Entry DOI10.2210/pdb2ooh/pdb
Related2OOW 2OOZ
DescriptorMacrophage migration inhibitory factor, SULFATE ION, 4-HYDROXYBENZALDEHYDE O-(CYCLOHEXYLCARBONYL)OXIME, ... (5 entities in total)
Functional Keywordsalternative ligand-binding modes, isomerase
Biological sourceHomo sapiens (human)
Cellular locationSecreted : P14174
Total number of polymer chains3
Total formula weight38512.44
Authors
Crichlow, G.V.,Al-Abed, Y.,Lolis, E. (deposition date: 2007-01-25, release date: 2007-06-05, Last modification date: 2023-08-30)
Primary citationCrichlow, G.V.,Cheng, K.F.,Dabideen, D.,Ochani, M.,Aljabari, B.,Pavlov, V.A.,Miller, E.J.,Lolis, E.,Al-Abed, Y.
Alternative chemical modifications reverse the binding orientation of a pharmacophore scaffold in the active site of macrophage migration inhibitory factor.
J.Biol.Chem., 282:23089-23095, 2007
Cited by
PubMed: 17526494
DOI: 10.1074/jbc.M701825200
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (1.85 Å)
Structure validation

217705

数据于2024-03-27公开中

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