2OO8

Synthesis, Structural Analysis, and SAR Studies of Triazine Derivatives as Potent, Selective Tie-2 Inhibitors

Summary for 2OO8

Entry DOI	10.2210/pdb2oo8/pdb
Descriptor	Angiopoietin-1 receptor, N-{3-[3-(DIMETHYLAMINO)PROPYL]-5-(TRIFLUOROMETHYL)PHENYL}-4-METHYL-3-[(3-PYRIMIDIN-4-YLPYRIDIN-2-YL)AMINO]BENZAMIDE (3 entities in total)
Functional Keywords	kinase, transferase
Biological source	Homo sapiens (human)
Cellular location	Membrane; Single-pass type I membrane protein: Q02763
Total number of polymer chains	1
Total formula weight	36787.90
Authors	Bellon, S.F.,Kim, J. (deposition date: 2007-01-25, release date: 2007-03-20, Last modification date: 2023-12-27)
Primary citation	Hodous, B.L.,Geuns-Meyer, S.D.,Hughes, P.E.,Albrecht, B.K.,Bellon, S.,Caenepeel, S.,Cee, V.J.,Chaffee, S.C.,Emery, M.,Fretland, J.,Gallant, P.,Gu, Y.,Johnson, R.E.,Kim, J.L.,Long, A.M.,Morrison, M.,Olivieri, P.R.,Patel, V.F.,Polverino, A.,Rose, P.,Wang, L.,Zhao, H. Synthesis, structural analysis, and SAR studies of triazine derivatives as potent, selective Tie-2 inhibitors. Bioorg.Med.Chem.Lett., 17:2886-2889, 2007 Cited by PubMed: 17350837 DOI: 10.1016/j.bmcl.2007.02.067 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.2 Å)

Structure validation