2OO8

Synthesis, Structural Analysis, and SAR Studies of Triazine Derivatives as Potent, Selective Tie-2 Inhibitors

2OO8 の概要

• エントリーDOI: 10.2210/pdb2oo8/pdb
• 分子名称: Angiopoietin-1 receptor, N-{3-[3-(DIMETHYLAMINO)PROPYL]-5-(TRIFLUOROMETHYL)PHENYL}-4-METHYL-3-[(3-PYRIMIDIN-4-YLPYRIDIN-2-YL)AMINO]BENZAMIDE (3 entities in total)
• 機能のキーワード: kinase, transferase
• 由来する生物種: Homo sapiens (human)
• 細胞内の位置: Membrane; Single-pass type I membrane protein: Q02763
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 36787.90

構造登録者

Bellon, S.F.,Kim, J. (登録日: 2007-01-25, 公開日: 2007-03-20, 最終更新日: 2023-12-27)

• 主引用文献: Hodous, B.L.,Geuns-Meyer, S.D.,Hughes, P.E.,Albrecht, B.K.,Bellon, S.,Caenepeel, S.,Cee, V.J.,Chaffee, S.C.,Emery, M.,Fretland, J.,Gallant, P.,Gu, Y.,Johnson, R.E.,Kim, J.L.,Long, A.M.,Morrison, M.,Olivieri, P.R.,Patel, V.F.,Polverino, A.,Rose, P.,Wang, L.,Zhao, H.; Synthesis, structural analysis, and SAR studies of triazine derivatives as potent, selective Tie-2 inhibitors.; Bioorg.Med.Chem.Lett., 17:2886-2889, 2007; PubMed: 17350837; DOI: 10.1016/j.bmcl.2007.02.067

実験手法

X-RAY DIFFRACTION (2.2 Å)