2OO4
Structure of LNR-HD (Negative Regulatory Region) from human Notch 2
Summary for 2OO4
Entry DOI | 10.2210/pdb2oo4/pdb |
Descriptor | Neurogenic locus notch homolog protein 2, CALCIUM ION, ZINC ION, ... (5 entities in total) |
Functional Keywords | alpha-beta-sandwich; sea domain; lnr; lin12 notch repeat; cysteine-rich; hd domain, cell cycle, signaling protein |
Biological source | Homo sapiens (human) |
Cellular location | Notch 2 extracellular truncation: Cell membrane ; Single-pass type I membrane protein . Notch 2 intracellular domain: Nucleus : Q04721 |
Total number of polymer chains | 2 |
Total formula weight | 52972.31 |
Authors | Gordon, W.R.,Vardar-Ulu, D.,Histen, G.,Sanchez-Irizarry, C.,Aster, J.C.,Blacklow, S.C. (deposition date: 2007-01-25, release date: 2007-04-03, Last modification date: 2023-12-27) |
Primary citation | Gordon, W.R.,Vardar-Ulu, D.,Histen, G.,Sanchez-Irizarry, C.,Aster, J.C.,Blacklow, S.C. Structural basis for autoinhibition of Notch Nat.Struct.Mol.Biol., 14:295-300, 2007 Cited by PubMed: 17401372DOI: 10.1038/nsmb1227 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.003 Å) |
Structure validation
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