2OM0

Structure of human insulin in presence of urea at pH 6.5

2OM0 の概要

• エントリーDOI: 10.2210/pdb2om0/pdb
• 関連するPDBエントリー: 2OLY 2OLZ 2OM1 2OMG 2OMH 2OMI
• 分子名称: Insulin A chain, Insulin B chain, RESORCINOL, ... (7 entities in total)
• 機能のキーワード: r6 conformation, hormone
• 由来する生物種: Homo sapiens (human); 詳細
• 細胞内の位置: Secreted: P01308 P01308
• タンパク質・核酸の鎖数: 36
• 化学式量合計: 108025.55

構造登録者

Norrman, M.,Schluckebier, G. (登録日: 2007-01-20, 公開日: 2007-12-04, 最終更新日: 2024-11-06)

主引用文献

Norrman, M.,Schluckebier, G.
Crystallographic characterization of two novel crystal forms of human insulin induced by chaotropic agents and a shift in pH.
Bmc Struct.Biol., 7:83-83, 2007

PubMed Abstract: Insulin is a therapeutic protein that is widely used for the treatment of diabetes. Its biological function was discovered more than 80 years ago and it has since then been characterized extensively. Crystallization of the insulin molecule has always been a key activity since the protein is often administered by subcutaneous injections of crystalline insulin formulations. Over the years, insulin has been crystallized and characterized in a number of crystal systems.

PubMed: 18093308
DOI: 10.1186/1472-6807-7-83

実験手法

X-RAY DIFFRACTION (2.05 Å)