2OLY

Structure of human insulin in presence of urea at pH 7.0

Summary for 2OLY

• Entry DOI: 10.2210/pdb2oly/pdb
• Related: 2OLZ 2OM0 2OM1 2OMG 2OMH 2OMI
• Descriptor: Insulin A chain, Insulin B chain, RESORCINOL, ... (8 entities in total)
• Functional Keywords: r6 conformation, hormone
• Biological source: Homo sapiens (human); More
• Cellular location: Secreted: P01308 P01308
• Total number of polymer chains: 12
• Total formula weight: 36607.36

Authors

Norrman, M.,Schluckebier, G. (deposition date: 2007-01-20, release date: 2007-12-04, Last modification date: 2024-10-30)

Primary citation

Norrman, M.,Schluckebier, G.
Crystallographic characterization of two novel crystal forms of human insulin induced by chaotropic agents and a shift in pH.
Bmc Struct.Biol., 7:83-83, 2007

PubMed Abstract: Insulin is a therapeutic protein that is widely used for the treatment of diabetes. Its biological function was discovered more than 80 years ago and it has since then been characterized extensively. Crystallization of the insulin molecule has always been a key activity since the protein is often administered by subcutaneous injections of crystalline insulin formulations. Over the years, insulin has been crystallized and characterized in a number of crystal systems.

PubMed: 18093308
DOI: 10.1186/1472-6807-7-83

Experimental method

X-RAY DIFFRACTION (1.7 Å)