Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

2OM0

Structure of human insulin in presence of urea at pH 6.5

Functional Information from GO Data

Chain	GOid	namespace	contents
1	0005179	molecular_function	hormone activity
1	0005576	cellular_component	extracellular region
2	0005179	molecular_function	hormone activity
2	0005576	cellular_component	extracellular region
3	0005179	molecular_function	hormone activity
3	0005576	cellular_component	extracellular region
4	0005179	molecular_function	hormone activity
4	0005576	cellular_component	extracellular region
a	0005179	molecular_function	hormone activity
a	0005576	cellular_component	extracellular region
A	0005179	molecular_function	hormone activity
A	0005576	cellular_component	extracellular region
b	0005179	molecular_function	hormone activity
b	0005576	cellular_component	extracellular region
B	0005179	molecular_function	hormone activity
B	0005576	cellular_component	extracellular region
c	0005179	molecular_function	hormone activity
c	0005576	cellular_component	extracellular region
C	0005179	molecular_function	hormone activity
C	0005576	cellular_component	extracellular region
d	0005179	molecular_function	hormone activity
d	0005576	cellular_component	extracellular region
D	0005179	molecular_function	hormone activity
D	0005576	cellular_component	extracellular region
e	0005179	molecular_function	hormone activity
e	0005576	cellular_component	extracellular region
E	0005179	molecular_function	hormone activity
E	0005576	cellular_component	extracellular region
f	0005179	molecular_function	hormone activity
f	0005576	cellular_component	extracellular region
F	0005179	molecular_function	hormone activity
F	0005576	cellular_component	extracellular region
g	0005179	molecular_function	hormone activity
g	0005576	cellular_component	extracellular region
G	0005179	molecular_function	hormone activity
G	0005576	cellular_component	extracellular region
h	0005179	molecular_function	hormone activity
h	0005576	cellular_component	extracellular region
H	0005179	molecular_function	hormone activity
H	0005576	cellular_component	extracellular region
i	0005179	molecular_function	hormone activity
i	0005576	cellular_component	extracellular region
I	0005179	molecular_function	hormone activity
I	0005576	cellular_component	extracellular region
j	0005179	molecular_function	hormone activity
j	0005576	cellular_component	extracellular region
J	0005179	molecular_function	hormone activity
J	0005576	cellular_component	extracellular region
k	0005179	molecular_function	hormone activity
k	0005576	cellular_component	extracellular region
K	0005179	molecular_function	hormone activity
K	0005576	cellular_component	extracellular region
l	0005179	molecular_function	hormone activity
l	0005576	cellular_component	extracellular region
L	0005179	molecular_function	hormone activity
L	0005576	cellular_component	extracellular region
Q	0005179	molecular_function	hormone activity
Q	0005576	cellular_component	extracellular region
R	0005179	molecular_function	hormone activity
R	0005576	cellular_component	extracellular region
S	0005179	molecular_function	hormone activity
S	0005576	cellular_component	extracellular region
T	0005179	molecular_function	hormone activity
T	0005576	cellular_component	extracellular region
U	0005179	molecular_function	hormone activity
U	0005576	cellular_component	extracellular region
V	0005179	molecular_function	hormone activity
V	0005576	cellular_component	extracellular region
X	0005179	molecular_function	hormone activity
X	0005576	cellular_component	extracellular region
Y	0005179	molecular_function	hormone activity
Y	0005576	cellular_component	extracellular region

Functional Information from PDB Data

site_id	AC1
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN B 801

Chain	Residue
B	HIS10
B	CL903
F	HIS10
J	HIS10

site_id	AC2
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN D 802

Chain	Residue
D	HIS10
D	CL904
H	HIS10
L	HIS10

site_id	AC3
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN R 803

Chain	Residue
R	CL905
T	HIS10
V	HIS10
R	HIS10

site_id	AC4
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN Y 804

Chain	Residue
2	HIS10
4	HIS10
Y	HIS10
Y	CL906

site_id	AC5
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN h 805

Chain	Residue
h	HIS10
h	CL901
j	HIS10
l	HIS10

site_id	AC6
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN b 806

Chain	Residue
b	HIS10
b	CL902
d	HIS10
f	HIS10

site_id	AC7
Number of Residues	4
Details	BINDING SITE FOR RESIDUE CL h 901

Chain	Residue
h	HIS10
h	ZN805
j	HIS10
l	HIS10

site_id	AC8
Number of Residues	4
Details	BINDING SITE FOR RESIDUE CL b 902

Chain	Residue
b	HIS10
b	ZN806
d	HIS10
f	HIS10

site_id	AC9
Number of Residues	4
Details	BINDING SITE FOR RESIDUE CL B 903

Chain	Residue
B	HIS10
B	ZN801
F	HIS10
J	HIS10

site_id	BC1
Number of Residues	4
Details	BINDING SITE FOR RESIDUE CL D 904

Chain	Residue
D	HIS10
D	ZN802
H	HIS10
L	HIS10

site_id	BC2
Number of Residues	4
Details	BINDING SITE FOR RESIDUE CL R 905

Chain	Residue
R	HIS10
R	ZN803
T	HIS10
V	HIS10

site_id	BC3
Number of Residues	4
Details	BINDING SITE FOR RESIDUE CL Y 906

Chain	Residue
2	HIS10
4	HIS10
Y	HIS10
Y	ZN804

site_id	BC4
Number of Residues	9
Details	BINDING SITE FOR RESIDUE RCO C 701

Chain	Residue
C	CYS6
C	SER9
C	ILE10
C	CYS11
C	HOH1025
D	LEU11
D	ALA14
J	LEU17
L	HIS5

site_id	BC5
Number of Residues	9
Details	BINDING SITE FOR RESIDUE RCO I 702

Chain	Residue
B	HIS5
D	LEU17
I	CYS6
I	SER9
I	ILE10
I	CYS11
I	HOH1009
J	LEU11
J	ALA14

site_id	BC6
Number of Residues	8
Details	BINDING SITE FOR RESIDUE RCO K 703

Chain	Residue
F	LEU17
H	HIS5
K	CYS6
K	ILE10
K	CYS11
K	HOH704
L	LEU11
L	ALA14

site_id	BC7
Number of Residues	8
Details	BINDING SITE FOR RESIDUE RCO U 704

Chain	Residue
R	HIS5
U	CYS6
U	SER9
U	ILE10
U	CYS11
U	HOH1013
V	LEU11
V	ALA14

site_id	BC8
Number of Residues	8
Details	BINDING SITE FOR RESIDUE RCO G 705

Chain	Residue
B	LEU17
D	HIS5
G	CYS6
G	ILE10
G	CYS11
G	HOH1018
H	LEU11
H	ALA14

site_id	BC9
Number of Residues	9
Details	BINDING SITE FOR RESIDUE RCO 3 706

Chain	Residue
2	HIS5
3	CYS6
3	SER9
3	ILE10
3	CYS11
3	HOH715
4	LEU11
4	ALA14
T	LEU17

site_id	CC1
Number of Residues	9
Details	BINDING SITE FOR RESIDUE RCO e 707

Chain	Residue
d	HIS5
e	CYS6
e	SER9
e	ILE10
e	CYS11
e	HOH708
f	LEU11
f	ALA14
h	LEU17

site_id	CC2
Number of Residues	9
Details	BINDING SITE FOR RESIDUE RCO k 708

Chain	Residue
d	LEU17
h	HIS5
k	CYS6
k	SER9
k	ILE10
k	CYS11
k	HOH709
l	LEU11
l	ALA14

site_id	CC3
Number of Residues	9
Details	BINDING SITE FOR RESIDUE RCO g 709

Chain	Residue
f	LEU17
g	CYS6
g	SER9
g	ILE10
g	CYS11
g	HOH1012
h	LEU11
h	ALA14
j	HIS5

site_id	CC4
Number of Residues	9
Details	BINDING SITE FOR RESIDUE RCO Q 710

Chain	Residue
2	LEU17
Q	CYS6
Q	SER9
Q	ILE10
Q	CYS11
Q	HOH1008
R	LEU11
R	ALA14
T	HIS5

site_id	CC5
Number of Residues	9
Details	BINDING SITE FOR RESIDUE RCO S 711

Chain	Residue
4	LEU17
S	CYS6
S	SER9
S	ILE10
S	CYS11
S	HOH1021
T	LEU11
T	ALA14
V	HIS5

site_id	CC6
Number of Residues	9
Details	BINDING SITE FOR RESIDUE RCO E 712

Chain	Residue
E	CYS6
E	SER9
E	ILE10
E	CYS11
E	HOH1016
F	LEU11
F	ALA14
J	HIS5
L	LEU17

site_id	CC7
Number of Residues	9
Details	BINDING SITE FOR RESIDUE RCO 1 713

Chain	Residue
1	CYS6
1	ILE10
1	CYS11
1	LEU16
1	HOH1024
2	LEU11
2	ALA14
R	LEU17
Y	HIS5

site_id	CC8
Number of Residues	8
Details	BINDING SITE FOR RESIDUE RCO A 714

Chain	Residue
A	CYS6
A	ILE10
A	CYS11
A	HOH1004
B	LEU11
B	ALA14
F	HIS5
H	LEU17

site_id	CC9
Number of Residues	8
Details	BINDING SITE FOR RESIDUE RCO c 715

Chain	Residue
b	HIS5
c	CYS6
c	ILE10
c	CYS11
c	HOH718
d	LEU11
d	ALA14
l	LEU17

site_id	DC1
Number of Residues	9
Details	BINDING SITE FOR RESIDUE RCO a 716

Chain	Residue
a	CYS6
a	SER9
a	ILE10
a	CYS11
a	HOH718
b	LEU11
b	ALA14
f	HIS5
j	LEU17

site_id	DC2
Number of Residues	9
Details	BINDING SITE FOR RESIDUE RCO i 717

Chain	Residue
b	LEU17
i	CYS6
i	SER9
i	ILE10
i	CYS11
i	HOH718
j	LEU11
j	ALA14
l	HIS5

site_id	DC3
Number of Residues	10
Details	BINDING SITE FOR RESIDUE RCO X 718

Chain	Residue
4	HIS5
V	LEU17
X	CYS6
X	SER9
X	ILE10
X	CYS11
X	HOH729
X	HOH741
Y	LEU11
Y	ALA14

site_id	DC4
Number of Residues	5
Details	BINDING SITE FOR RESIDUE URE A 1001

Chain	Residue
A	GLN5
A	SER9
A	ILE10
A	CYS11
A	GLN15

site_id	DC5
Number of Residues	5
Details	BINDING SITE FOR RESIDUE URE C 1002

Chain	Residue
C	GLN5
C	SER9
C	ILE10
C	CYS11
C	GLN15

site_id	DC6
Number of Residues	4
Details	BINDING SITE FOR RESIDUE URE E 1003

Chain	Residue
E	GLN5
E	SER9
E	ILE10
E	GLN15

site_id	DC7
Number of Residues	5
Details	BINDING SITE FOR RESIDUE URE G 1004

Chain	Residue
G	GLN5
G	SER9
G	ILE10
G	CYS11
G	GLN15

site_id	DC8
Number of Residues	5
Details	BINDING SITE FOR RESIDUE URE I 1005

Chain	Residue
I	GLN5
I	SER9
I	ILE10
I	CYS11
I	GLN15

site_id	DC9
Number of Residues	5
Details	BINDING SITE FOR RESIDUE URE Q 1006

Chain	Residue
Q	GLN5
Q	SER9
Q	ILE10
Q	CYS11
Q	GLN15

site_id	EC1
Number of Residues	5
Details	BINDING SITE FOR RESIDUE URE S 1007

Chain	Residue
S	GLN5
S	SER9
S	ILE10
S	CYS11
S	GLN15

site_id	EC2
Number of Residues	5
Details	BINDING SITE FOR RESIDUE URE 1 1008

Chain	Residue
1	GLN5
1	SER9
1	ILE10
1	CYS11
1	GLN15

site_id	EC3
Number of Residues	5
Details	BINDING SITE FOR RESIDUE URE g 1009

Chain	Residue
g	GLN5
g	SER9
g	ILE10
g	CYS11
g	GLN15

site_id	EC4
Number of Residues	6
Details	BINDING SITE FOR RESIDUE URE D 1010

Chain	Residue
D	LEU6
D	HOH1011
D	HOH1034
G	CYS7
H	ASN3
H	CYS7

site_id	EC5
Number of Residues	2
Details	BINDING SITE FOR RESIDUE URE d 1011

Chain	Residue
d	HIS5
h	GLY20

site_id	EC6
Number of Residues	3
Details	BINDING SITE FOR RESIDUE URE U 1012

Chain	Residue
U	SER12
U	HOH1024
U	HOH1026

Functional Information from PROSITE/UniProt

site_id	PS00262
Number of Residues	15
Details	INSULIN Insulin family signature. CCTSiCSlyqLenyC

Chain	Residue	Details
A	CYS6-CYS20

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	360
Details	Peptide: {"description":"Insulin A chain","featureId":"PRO_0000015821"}

Chain

Residue

Details

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)
		EDMap 2fo-fc (MTZ)