2OJW
Crystal structure of human glutamine synthetase in complex with ADP and phosphate
Summary for 2OJW
Entry DOI | 10.2210/pdb2ojw/pdb |
Descriptor | Glutamine synthetase, MANGANESE (II) ION, PHOSPHATE ION, ... (7 entities in total) |
Functional Keywords | amino-acid biosynthesis, ligase, synthetase, structural genomics, structural genomics consortium, sgc |
Biological source | Homo sapiens (human) |
Cellular location | Cytoplasm: P15104 |
Total number of polymer chains | 5 |
Total formula weight | 221263.31 |
Authors | Karlberg, T.,Uppenberg, J.,Arrowsmith, C.,Berglund, H.,Busam, R.D.,Collins, R.,Edwards, A.,Flodin, S.,Flores, A.,Graslund, S.,Hallberg, B.M.,Hammarstrom, M.,Hogbom, M.,Johansson, I.,Kotenyova, T.,Moche, M.,Nilsson, M.E.,Nordlund, P.,Nyman, T.,Ogg, D.,Persson, C.,Sagemark, J.,Stenmark, P.,Sundstrom, M.,Thorsell, A.G.,Van Den Berg, S.,Wallden, K.,Weigelt, J.,Holmberg-Schiavone, L.,Structural Genomics Consortium (SGC) (deposition date: 2007-01-15, release date: 2007-03-13, Last modification date: 2023-08-30) |
Primary citation | Krajewski, W.W.,Collins, R.,Holmberg-Schiavone, L.,Jones, T.A.,Karlberg, T.,Mowbray, S.L. Crystal structures of mammalian glutamine synthetases illustrate substrate-induced conformational changes and provide opportunities for drug and herbicide design. J.Mol.Biol., 375:217-228, 2008 Cited by PubMed: 18005987DOI: 10.1016/j.jmb.2007.10.029 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.05 Å) |
Structure validation
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