2OJ9

Structure of IGF-1R kinase domain complexed with a benzimidazole inhibitor

2OJ9 の概要

• エントリーDOI: 10.2210/pdb2oj9/pdb
• 分子名称: Insulin-like growth factor 1 receptor precursor (EC 2.7.10.1) (Insulin-like growth factor I receptor) (IGF-I receptor) (CD221 antigen), 3-[5-(1H-IMIDAZOL-1-YL)-7-METHYL-1H-BENZIMIDAZOL-2-YL]-4-[(PYRIDIN-2-YLMETHYL)AMINO]PYRIDIN-2(1H)-ONE (3 entities in total)
• 機能のキーワード: hormone/growth factor, igf-1r, kinase domain, transferase
• 由来する生物種: Homo sapiens (human)
• 細胞内の位置: Membrane; Single-pass type I membrane protein: P08069
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 35438.66

構造登録者

Sack, J.S.,Jacobson, B.L. (登録日: 2007-01-12, 公開日: 2007-05-01, 最終更新日: 2023-12-27)

• 主引用文献: Velaparthi, U.,Wittman, M.,Liu, P.,Stoffan, K.,Zimmermann, K.,Sang, X.,Carboni, J.,Li, A.,Attar, R.,Gottardis, M.,Greer, A.,Chang, C.Y.,Jacobsen, B.L.,Sack, J.S.,Sun, Y.,Langley, D.R.,Balasubramanian, B.,Vyas, D.; Discovery and initial SAR of 3-(1H-benzo[d]imidazol-2-yl)pyridin-2(1H)-ones as inhibitors of insulin-like growth factor 1-receptor (IGF-1R).; Bioorg.Med.Chem.Lett., 17:2317-2321, 2007; PubMed: 17317169; DOI: 10.1016/j.bmcl.2007.01.102

実験手法

X-RAY DIFFRACTION (2 Å)