2OIP

Crystal Structure of the S290G Active Site Mutant of TS-DHFR from Cryptosporidium hominis

2OIP の概要

• エントリーDOI: 10.2210/pdb2oip/pdb
• 分子名称: Chain A, crystal structure of Dhfr, 2'-DEOXYURIDINE 5'-MONOPHOSPHATE, 10-PROPARGYL-5,8-DIDEAZAFOLIC ACID, ... (6 entities in total)
• 機能のキーワード: bifunctional enzyme, transferase, oxidoreductase
• 由来する生物種: Cryptosporidium hominis
• タンパク質・核酸の鎖数: 5
• 化学式量合計: 309998.65

構造登録者

Martucci, W.E.,Vargo, M.A. (登録日: 2007-01-11, 公開日: 2007-07-17, 最終更新日: 2023-08-30)

• 主引用文献: Doan, L.T.,Martucci, W.E.,Vargo, M.A.,Atreya, C.E.,Anderson, K.S.; Nonconserved residues Ala287 and Ser290 of the Cryptosporidium hominis thymidylate synthase domain facilitate its rapid rate of catalysis; Biochemistry, 46:8379-8391, 2007; PubMed: 17580969; DOI: 10.1021/bi700531r

実験手法