2OI0
Crystal structure analysis 0f the TNF-a Coverting Enzyme (TACE) in complexed with Aryl-sulfonamide
Summary for 2OI0
Entry DOI | 10.2210/pdb2oi0/pdb |
Descriptor | TNF- a Converting Enzyme (TACE), ZINC ION, (3S)-1-{[4-(BUT-2-YN-1-YLOXY)PHENYL]SULFONYL}PYRROLIDINE-3-THIOL, ... (4 entities in total) |
Functional Keywords | tnf-a coverting enzyme, aryl-sulfonamide, tace inhibitors, hydrolase |
Biological source | Homo sapiens (human) |
Cellular location | Membrane; Single-pass type I membrane protein: P78536 |
Total number of polymer chains | 1 |
Total formula weight | 30413.49 |
Authors | Wei, Y.,Rao, G.B.,Bandarage, U.K. (deposition date: 2007-01-10, release date: 2007-11-27, Last modification date: 2023-08-30) |
Primary citation | Govinda Rao, B.,Bandarage, U.K.,Wang, T.,Come, J.H.,Perola, E.,Wei, Y.,Tian, S.K.,Saunders, J.O. Novel thiol-based TACE inhibitors: rational design, synthesis, and SAR of thiol-containing aryl sulfonamides Bioorg.Med.Chem.Lett., 17:2250-2253, 2007 Cited by PubMed: 17289381DOI: 10.1016/j.bmcl.2007.01.064 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2 Å) |
Structure validation
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