2OI0

Crystal structure analysis 0f the TNF-a Coverting Enzyme (TACE) in complexed with Aryl-sulfonamide

2OI0 の概要

• エントリーDOI: 10.2210/pdb2oi0/pdb
• 分子名称: TNF- a Converting Enzyme (TACE), ZINC ION, (3S)-1-{[4-(BUT-2-YN-1-YLOXY)PHENYL]SULFONYL}PYRROLIDINE-3-THIOL, ... (4 entities in total)
• 機能のキーワード: tnf-a coverting enzyme, aryl-sulfonamide, tace inhibitors, hydrolase
• 由来する生物種: Homo sapiens (human)
• 細胞内の位置: Membrane; Single-pass type I membrane protein: P78536
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 30413.49

構造登録者

Wei, Y.,Rao, G.B.,Bandarage, U.K. (登録日: 2007-01-10, 公開日: 2007-11-27, 最終更新日: 2023-08-30)

• 主引用文献: Govinda Rao, B.,Bandarage, U.K.,Wang, T.,Come, J.H.,Perola, E.,Wei, Y.,Tian, S.K.,Saunders, J.O.; Novel thiol-based TACE inhibitors: rational design, synthesis, and SAR of thiol-containing aryl sulfonamides; Bioorg.Med.Chem.Lett., 17:2250-2253, 2007; PubMed: 17289381; DOI: 10.1016/j.bmcl.2007.01.064

実験手法

X-RAY DIFFRACTION (2 Å)