2OGM
The crystal structure of the large ribosomal subunit from Deinococcus radiodurans complexed with the pleuromutilin derivative SB-571519
Summary for 2OGM
Entry DOI | 10.2210/pdb2ogm/pdb |
Descriptor | 23S ribosomal RNA, 50S ribosomal protein L3, (2S,3AR,4R,5S,6S,8R,9R,9AR,10R)-2,5-DIHYDROXY-4,6,9,10-TETRAMETHYL-1-OXO-6-VINYLDECAHYDRO-3A,9-PROP[1]ENOCYCLOPENTA[8]ANNULEN-8-YL [(6-AMINOPYRIDAZIN-3-YL)CARBONYL]CARBAMATE (3 entities in total) |
Functional Keywords | sb-571519, pleuromutilin, ptc, peptidyl transferase center, ribosome, antibiotic |
Biological source | Deinococcus radiodurans More |
Total number of polymer chains | 2 |
Total formula weight | 956380.72 |
Authors | Davidovich, C.,Bashan, A.,Auerbach-Nevo, T.,Yonath, A. (deposition date: 2007-01-07, release date: 2007-05-01, Last modification date: 2023-12-27) |
Primary citation | Davidovich, C.,Bashan, A.,Auerbach-Nevo, T.,Yaggie, R.D.,Gontarek, R.R.,Yonath, A. Induced-fit tightens pleuromutilins binding to ribosomes and remote interactions enable their selectivity. Proc.Natl.Acad.Sci.Usa, 104:4291-4296, 2007 Cited by PubMed: 17360517DOI: 10.1073/pnas.0700041104 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (3.5 Å) |
Structure validation
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