2OGM

The crystal structure of the large ribosomal subunit from Deinococcus radiodurans complexed with the pleuromutilin derivative SB-571519

Summary for 2OGM

Entry DOI	10.2210/pdb2ogm/pdb
Descriptor	23S ribosomal RNA, 50S ribosomal protein L3, (2S,3AR,4R,5S,6S,8R,9R,9AR,10R)-2,5-DIHYDROXY-4,6,9,10-TETRAMETHYL-1-OXO-6-VINYLDECAHYDRO-3A,9-PROP[1]ENOCYCLOPENTA[8]ANNULEN-8-YL [(6-AMINOPYRIDAZIN-3-YL)CARBONYL]CARBAMATE (3 entities in total)
Functional Keywords	sb-571519, pleuromutilin, ptc, peptidyl transferase center, ribosome, antibiotic
Biological source	Deinococcus radiodurans More
Total number of polymer chains	2
Total formula weight	956380.72
Authors	Davidovich, C.,Bashan, A.,Auerbach-Nevo, T.,Yonath, A. (deposition date: 2007-01-07, release date: 2007-05-01, Last modification date: 2023-12-27)
Primary citation	Davidovich, C.,Bashan, A.,Auerbach-Nevo, T.,Yaggie, R.D.,Gontarek, R.R.,Yonath, A. Induced-fit tightens pleuromutilins binding to ribosomes and remote interactions enable their selectivity. Proc.Natl.Acad.Sci.Usa, 104:4291-4296, 2007 Cited by PubMed: 17360517 DOI: 10.1073/pnas.0700041104 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (3.5 Å)

Structure validation