2OF4

crystal structure of furanopyrimidine 1 bound to lck

Summary for 2OF4

Entry DOI	10.2210/pdb2of4/pdb
Related	2OF2
Descriptor	Proto-oncogene tyrosine-protein kinase LCK, 5,6-DIPHENYL-N-(2-PIPERAZIN-1-YLETHYL)FURO[2,3-D]PYRIMIDIN-4-AMINE (3 entities in total)
Functional Keywords	lck, kinase domain, transferase
Biological source	Homo sapiens (human)
Cellular location	Cytoplasm: P06239
Total number of polymer chains	1
Total formula weight	31745.38
Authors	Martin, M.W. (deposition date: 2007-01-02, release date: 2007-02-27, Last modification date: 2023-08-30)
Primary citation	Martin, M.W.,Newcomb, J.,Nunes, J.J.,Bemis, J.E.,McGowan, D.C.,White, R.D.,Buchanan, J.L.,Dimauro, E.F.,Boucher, C.,Faust, T.,Hsieh, F.,Huang, X.,Lee, J.H.,Schneider, S.,Turci, S.M.,Zhu, X. Discovery of novel 2,3-diarylfuro[2,3-b]pyridin-4-amines as potent and selective inhibitors of Lck: Synthesis, SAR, and pharmacokinetic properties. Bioorg.Med.Chem.Lett., 17:2299-2304, 2007 Cited by PubMed Abstract: 2,3-Diarylfuro[2,3-b]pyridine-4-amines are a novel class of potent and selective inhibitors of Lck. The discovery, synthesis, and structure activity relationships of this series of inhibitors are reported. The most promising compounds were also profiled to deduce their pharmacokinetic properties. PubMed: 17276681 DOI: 10.1016/j.bmcl.2007.01.048 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.7 Å)

Structure validation