2ODJ

Crystal structure of the outer membrane protein OprD from Pseudomonas aeruginosa

2ODJ の概要

• エントリーDOI: 10.2210/pdb2odj/pdb
• 分子名称: Porin D, (HYDROXYETHYLOXY)TRI(ETHYLOXY)OCTANE (2 entities in total)
• 機能のキーワード: outer membrane protein, beta-barrel, amino acid transport, membrane protein
• 由来する生物種: Pseudomonas aeruginosa
• 細胞内の位置: Cell outer membrane; Multi-pass membrane protein: P32722
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 97339.25

構造登録者

Biswas, S.,van den Berg, B. (登録日: 2006-12-22, 公開日: 2007-10-16, 最終更新日: 2024-10-30)

主引用文献

Biswas, S.,Mohammad, M.M.,Patel, D.R.,Movileanu, L.,van den Berg, B.
Structural insight into OprD substrate specificity.
Nat.Struct.Mol.Biol., 14:1108-1109, 2007

PubMed Abstract: OprD proteins form a large family of substrate-specific outer-membrane channels in Gram-negative bacteria. We report here the X-ray crystal structure of OprD from Pseudomonas aeruginosa, which reveals a monomeric 18-stranded beta-barrel characterized by a very narrow pore constriction, with a positively charged basic ladder on one side and an electronegative pocket on the other side. The location of highly conserved residues in OprD suggests that the structure represents the general architecture of OprD channels.

PubMed: 17952093
DOI: 10.1038/nsmb1304

実験手法

X-RAY DIFFRACTION (2.9 Å)