2ODE

Crystal structure of the heterodimeric complex of human RGS8 and activated Gi alpha 3

2ODE の概要

• エントリーDOI: 10.2210/pdb2ode/pdb
• 分子名称: Guanine nucleotide-binding protein G(k) subunit alpha, Regulator of G-protein signaling 8, TETRAFLUOROALUMINATE ION, ... (6 entities in total)
• 機能のキーワード: g protein signalling, rgs, heterotrimeric g protein, signalling complex, structural genomics, structural genomics consortium, sgc, signaling protein
• 由来する生物種: Homo sapiens (human); 詳細
• 細胞内の位置: Cytoplasm: P08754
• タンパク質・核酸の鎖数: 4
• 化学式量合計: 114703.90

構造登録者

Gileadi, C.,Soundararajan, M.,Turnbull, A.P.,Elkins, J.M.,Papagrigoriou, E.,Pike, A.C.W.,Bunkoczi, G.,Gorrec, F.,Umeano, C.,von Delft, F.,Weigelt, J.,Edwards, A.,Arrowsmith, C.H.,Sundstrom, M.,Doyle, D.A.,Structural Genomics Consortium (SGC) (登録日: 2006-12-22, 公開日: 2007-02-06, 最終更新日: 2023-08-30)

• 主引用文献: Soundararajan, M.,Willard, F.S.,Kimple, A.J.,Turnbull, A.P.,Ball, L.J.,Schoch, G.A.,Gileadi, C.,Fedorov, O.Y.,Dowler, E.F.,Higman, V.A.,Hutsell, S.Q.,Sundstrom, M.,Doyle, D.A.,Siderovski, D.P.; Structural diversity in the RGS domain and its interaction with heterotrimeric G protein alpha-subunits.; Proc.Natl.Acad.Sci.Usa, 105:6457-6462, 2008; PubMed: 18434541; DOI: 10.1073/pnas.0801508105

実験手法

X-RAY DIFFRACTION (1.9 Å)