2OCF
Human estrogen receptor alpha ligand-binding domain in complex with estradiol and the E2#23 FN3 monobody
Summary for 2OCF
Entry DOI | 10.2210/pdb2ocf/pdb |
Descriptor | Estrogen receptor, Fibronectin, ESTRADIOL, ... (4 entities in total) |
Functional Keywords | estrogen receptor, lbd, monobody, estradiol, hormone-growth factor complex, hormone/growth factor |
Biological source | Homo sapiens (human) More |
Cellular location | Isoform 1: Nucleus . Isoform 3: Nucleus. Nucleus: P03372 Secreted, extracellular space, extracellular matrix: P02751 |
Total number of polymer chains | 2 |
Total formula weight | 47197.40 |
Authors | Rajan, S.S.,Kuruvilla, S.M.,Sharma, S.K.,Kim, Y.,Huang, J.,Koide, A.,Koide, S.,Joachimiak, A.,Greene, G.L. (deposition date: 2006-12-20, release date: 2007-11-06, Last modification date: 2023-08-30) |
Primary citation | Koide, A.,Abbatiello, S.,Rothgery, L.,Koide, S. Probing protein conformational changes in living cells by using designer binding proteins: application to the estrogen receptor. Proc.Natl.Acad.Sci.USA, 99:1253-1258, 2002 Cited by PubMed: 11818562DOI: 10.1073/pnas.032665299 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.95 Å) |
Structure validation
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