2OBJ
Crystal structure of human PIM-1 Kinase in complex with inhibitor
Summary for 2OBJ
Entry DOI | 10.2210/pdb2obj/pdb |
Related | 1XQZ |
Descriptor | Proto-oncogene serine/threonine-protein kinase Pim-1, 6-(5-BROMO-2-HYDROXYPHENYL)-2-OXO-4-PHENYL-1,2-DIHYDROPYRIDINE-3-CARBONITRILE (3 entities in total) |
Functional Keywords | pim, pim-1, pim1, human pim-1 kinase, serine/threonine kinase, kinase inhibitor complex, pyridone, kinase inhibitor, transferase |
Biological source | Homo sapiens (human) |
Cellular location | Isoform 2: Cytoplasm. Isoform 1: Cell membrane: P11309 |
Total number of polymer chains | 1 |
Total formula weight | 38351.27 |
Authors | Yao, N.,Cheney, I.W.,Yan, S. (deposition date: 2006-12-19, release date: 2007-02-06, Last modification date: 2023-08-30) |
Primary citation | Cheney, I.W.,Yan, S.,Appleby, T.,Walker, H.,Vo, T.,Yao, N.,Hamatake, R.,Hong, Z.,Wu, J.Z. Identification and structure-activity relationships of substituted pyridones as inhibitors of Pim-1 kinase. Bioorg.Med.Chem.Lett., 17:1679-1683, 2007 Cited by PubMed: 17251021DOI: 10.1016/j.bmcl.2006.12.086 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.5 Å) |
Structure validation
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