2O9I
Crystal Structure of the Human Pregnane X Receptor LBD in complex with an SRC-1 coactivator peptide and T0901317
Summary for 2O9I
Entry DOI | 10.2210/pdb2o9i/pdb |
Related | 1ILG 1ILH 1M13 1NRL 1SKX |
Descriptor | Orphan nuclear receptor PXR, Nuclear Receptor Coactivator 1 isoform 3, N-(2,2,2-TRIFLUOROETHYL)-N-{4-[2,2,2-TRIFLUORO-1-HYDROXY-1-(TRIFLUOROMETHYL)ETHYL]PHENYL}BENZENESULFONAMIDE, ... (4 entities in total) |
Functional Keywords | nuclear receptor, pregnane x receptor, pxr, t0901317, transcription |
Biological source | Homo sapiens (human) More |
Cellular location | Nucleus: O75469 |
Total number of polymer chains | 4 |
Total formula weight | 72072.91 |
Authors | Xue, Y.,Redinbo, M.R. (deposition date: 2006-12-13, release date: 2007-01-30, Last modification date: 2023-08-30) |
Primary citation | Xue, Y.,Chao, E.,Zuercher, W.J.,Willson, T.M.,Collins, J.L.,Redinbo, M.R. Crystal structure of the PXR-T1317 complex provides a scaffold to examine the potential for receptor antagonism. Bioorg.Med.Chem., 15:2156-2166, 2007 Cited by PubMed: 17215127DOI: 10.1016/j.bmc.2006.12.026 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.8 Å) |
Structure validation
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