2O45
Structure of the 23S rRNA of the large ribosomal subunit from Deinococcus Radiodurans in complex with the macrolide RU-69874
Summary for 2O45
Entry DOI | 10.2210/pdb2o45/pdb |
Related | 2O43 2O44 |
Descriptor | 23S rRNA, (3AS,4R,7R,8S,9S,10R,11R,13R,15R,15AR)-4-ETHYL-11-METHOXY-3A,7,9,11,13,15-HEXAMETHYL-2,6,14-TRIOXO-1-[4-(4-PYRIDIN-3-YL-1H-IMIDAZOL-1-YL)BUTYL]-10-{[3,4,6-TRIDEOXY-3-(DIMETHYLAMINO)-BETA-D-XYLO-HEXOPYRANOSYL]OXY}TETRADECAHYDRO-2H-OXACYCLOTETRADECINO[4,3-D][1,3]OXAZOL-8-YL 2,6-DIDEOXY-3-C-METHYL-3-O-METHYL-ALPHA-L-RIBO-HEXOPYRANOSIDE (2 entities in total) |
Functional Keywords | ribosome, macrolides, tunnel, rna |
Biological source | Deinococcus radiodurans |
Total number of polymer chains | 1 |
Total formula weight | 934377.21 |
Authors | Baram, D.,Pyetan, E.,Auerbach-Nevo, T.,Yonath, A. (deposition date: 2006-12-03, release date: 2007-12-04, Last modification date: 2023-08-30) |
Primary citation | Baram, D.,Pyetan, E.,Auerbach-Nevo, T.,Yonath, A. Chemical Parameters Influencing Fine Tuning in the Binding of Macrolide Antibiotics to the Ribosomal Tunnel TO BE PUBLISHED, |
Experimental method | X-RAY DIFFRACTION (3.6 Å) |
Structure validation
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