2O39

Human Adenovirus type 11 knob in complex with domains SCR1 and SCR2 of CD46 (membrane cofactor protein, MCP)

2O39 の概要

• エントリーDOI: 10.2210/pdb2o39/pdb
• 関連するPDBエントリー: 1CKL
• 分子名称: Fiber protein, Membrane cofactor protein, beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... (5 entities in total)
• 機能のキーワード: membrane cofactor protein, mcp, cd46, adenovirus, fiber knob, ad11, virus receptor complex, scr, short consensus repeat, ccp, complement control protein, viral protein-immune system complex, viral protein/immune system
• 由来する生物種: Human adenovirus 11p; 詳細
• 細胞内の位置: Cytoplasmic vesicle, secretory vesicle, acrosome inner membrane; Single-pass type I membrane protein: P15529
• タンパク質・核酸の鎖数: 4
• 化学式量合計: 74421.51

構造登録者

Persson, D.B.,Reiter, D.M.,Arnberg, N.,Stehle, T. (登録日: 2006-12-01, 公開日: 2007-01-09, 最終更新日: 2024-10-30)

主引用文献

Persson, B.D.,Reiter, D.M.,Marttila, M.,Mei, Y.F.,Casasnovas, J.M.,Arnberg, N.,Stehle, T.
Adenovirus type 11 binding alters the conformation of its receptor CD46.
Nat.Struct.Mol.Biol., 14:164-166, 2007

PubMed Abstract: Adenoviruses (Ads) are important human pathogens and valuable gene delivery vehicles. We report here the crystal structure of the species B Ad11 knob complexed with the Ad11-binding region of its receptor CD46. The conformation of bound CD46 differs profoundly from its unbound state, with the bent surface structure straightened into an elongated rod. This mechanism of interaction is likely to be conserved among many pathogens that target CD46 or related molecules.

PubMed: 17220899
DOI: 10.1038/nsmb1190

実験手法

X-RAY DIFFRACTION (2.85 Å)