2O1O

Cryptosporidium parvum putative polyprenyl pyrophosphate synthase (cgd4_2550) in complex with risedronate.

Summary for 2O1O

• Entry DOI: 10.2210/pdb2o1o/pdb
• Related: 2HER
• Descriptor: Putative farnesyl pyrophosphate synthase, MAGNESIUM ION, 1-HYDROXY-2-(3-PYRIDINYL)ETHYLIDENE BIS-PHOSPHONIC ACID, ... (4 entities in total)
• Functional Keywords: putative polyprenyl pyrophosphate synthase, structural genomics, structural genomics consortium, sgc, unknown function
• Biological source: Cryptosporidium parvum
• Total number of polymer chains: 2
• Total formula weight: 86658.16

Authors

Chruszcz, M.,Artz, J.D.,Dong, A.,Dunford, J.,Lew, J.,Zhao, Y.,Kozieradski, I.,Kavanaugh, K.L.,Oppermann, U.,Sundstrom, M.,Weigelt, J.,Edwards, A.M.,Arrowsmith, C.H.,Bochkarev, A.,Hui, R.,Minor, W.,Structural Genomics Consortium (SGC) (deposition date: 2006-11-29, release date: 2006-12-12, Last modification date: 2023-08-30)

• Primary citation: Artz, J.D.,Dunford, J.E.,Arrowood, M.J.,Dong, A.,Chruszcz, M.,Kavanagh, K.L.,Minor, W.,Russell, R.G.,Ebetino, F.H.,Oppermann, U.,Hui, R.; Targeting a uniquely nonspecific prenyl synthase with bisphosphonates to combat cryptosporidiosis; Chem.Biol., 15:1296-1306, 2008; PubMed: 19101474; DOI: 10.1016/j.chembiol.2008.10.017

Experimental method

X-RAY DIFFRACTION (2.42 Å)