2NWN
New Pharmacophore for Serine Protease Inhibition Revealed by Crystal Structure of Human Urokinase-type Plasminogen Activator Complexed with a Cyclic Peptidyl Inhibitor, upain-1
Summary for 2NWN
Entry DOI | 10.2210/pdb2nwn/pdb |
Descriptor | Plasminogen activator, urokinase, upain-1 (3 entities in total) |
Functional Keywords | urokinase-type plasminogen activator, peptidyl inhibitor, pharmacophore, structural genomics, structural genomics consortium, sgc, hydrolase |
Biological source | Homo sapiens (human) More |
Total number of polymer chains | 2 |
Total formula weight | 29937.12 |
Authors | Zhao, G.,Yuan, C.,Wind, T.,Andreasen, P.A.,Huang, Z.,Huang, M.,Structural Genomics Consortium (SGC) (deposition date: 2006-11-16, release date: 2007-10-16, Last modification date: 2023-10-25) |
Primary citation | Zhao, G.,Yuan, C.,Wind, T.,Huang, Z.,Andreasen, P.A.,Huang, M. Structural basis of specificity of a peptidyl urokinase inhibitor, upain-1 J.Struct.Biol., 160:1-10, 2007 Cited by PubMed: 17692534DOI: 10.1016/j.jsb.2007.06.003 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.15 Å) |
Structure validation
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