2NW4
Crystal Structure of the Rat Androgen Receptor Ligand Binding Domain Complex with BMS-564929
Summary for 2NW4
Entry DOI | 10.2210/pdb2nw4/pdb |
Descriptor | Androgen receptor, 2-CHLORO-4-[(7R,7AS)-7-HYDROXY-1,3-DIOXOTETRAHYDRO-1H-PYRROLO[1,2-C]IMIDAZOL-2(3H)-YL]-3-METHYLBENZONITRILE (3 entities in total) |
Functional Keywords | androgen receptor, steroid receptor, nuclear receptor, transcription regulation, ligand-binding domain, hormone-growth factor complex, hormone/growth factor |
Biological source | Rattus norvegicus (Norway rat) |
Cellular location | Nucleus: P15207 |
Total number of polymer chains | 1 |
Total formula weight | 30588.13 |
Authors | Ostrowski, J.,Kuhns, J.E.,Lupisella, J.A.,Manfredi, M.C.,Beehler, B.C.,Krystek, S.R.,Bi, Y.,Sun, C.,Seethala, R.,Golla, R.,Sleph, P.G.,Fura, A.,An, Y.,Kish, K.F.,Sack, J.S.,Mookhtiar, K.A.,Grover, G.J.,Hamann, L.G. (deposition date: 2006-11-14, release date: 2006-12-12, Last modification date: 2023-08-30) |
Primary citation | Ostrowski, J.,Kuhns, J.E.,Lupisella, J.A.,Manfredi, M.C.,Beehler, B.C.,Krystek, S.R.,Bi, Y.,Sun, C.,Seethala, R.,Golla, R.,Sleph, P.G.,Fura, A.,An, Y.,Kish, K.F.,Sack, J.S.,Mookhtiar, K.A.,Grover, G.J.,Hamann, L.G. Pharmacological and x-ray structural characterization of a novel selective androgen receptor modulator: potent hyperanabolic stimulation of skeletal muscle with hypostimulation of prostate in rats. Endocrinology, 148:4-12, 2007 Cited by PubMed: 17008401DOI: 10.1210/en.2006-0843 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (3 Å) |
Structure validation
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