2NW4

Crystal Structure of the Rat Androgen Receptor Ligand Binding Domain Complex with BMS-564929

2NW4 の概要

• エントリーDOI: 10.2210/pdb2nw4/pdb
• 分子名称: Androgen receptor, 2-CHLORO-4-[(7R,7AS)-7-HYDROXY-1,3-DIOXOTETRAHYDRO-1H-PYRROLO[1,2-C]IMIDAZOL-2(3H)-YL]-3-METHYLBENZONITRILE (3 entities in total)
• 機能のキーワード: androgen receptor, steroid receptor, nuclear receptor, transcription regulation, ligand-binding domain, hormone-growth factor complex, hormone/growth factor
• 由来する生物種: Rattus norvegicus (Norway rat)
• 細胞内の位置: Nucleus: P15207
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 30588.13

構造登録者

Ostrowski, J.,Kuhns, J.E.,Lupisella, J.A.,Manfredi, M.C.,Beehler, B.C.,Krystek, S.R.,Bi, Y.,Sun, C.,Seethala, R.,Golla, R.,Sleph, P.G.,Fura, A.,An, Y.,Kish, K.F.,Sack, J.S.,Mookhtiar, K.A.,Grover, G.J.,Hamann, L.G. (登録日: 2006-11-14, 公開日: 2006-12-12, 最終更新日: 2023-08-30)

• 主引用文献: Ostrowski, J.,Kuhns, J.E.,Lupisella, J.A.,Manfredi, M.C.,Beehler, B.C.,Krystek, S.R.,Bi, Y.,Sun, C.,Seethala, R.,Golla, R.,Sleph, P.G.,Fura, A.,An, Y.,Kish, K.F.,Sack, J.S.,Mookhtiar, K.A.,Grover, G.J.,Hamann, L.G.; Pharmacological and x-ray structural characterization of a novel selective androgen receptor modulator: potent hyperanabolic stimulation of skeletal muscle with hypostimulation of prostate in rats.; Endocrinology, 148:4-12, 2007; PubMed: 17008401; DOI: 10.1210/en.2006-0843

実験手法

X-RAY DIFFRACTION (3 Å)