2NTA

Crystal Structure of PTP1B-inhibitor Complex

Summary for 2NTA

Entry DOI	10.2210/pdb2nta/pdb
Related	2HCE 2HCX 2HFA 2NT7
Descriptor	Tyrosine-protein phosphatase non-receptor type 1, 5-(4-CHLORO-5-PHENYL-3-THIENYL)-1,2,5-THIADIAZOLIDIN-3-ONE 1,1-DIOXIDE (3 entities in total)
Functional Keywords	ptp1b, protein-inhibitor complex, hydrolase
Biological source	Homo sapiens (human)
Cellular location	Endoplasmic reticulum membrane; Peripheral membrane protein; Cytoplasmic side: P18031
Total number of polymer chains	1
Total formula weight	35148.49
Authors	Xu, W.,Follows, B. (deposition date: 2006-11-07, release date: 2007-04-17, Last modification date: 2023-12-27)
Primary citation	Wan, Z.K.,Follows, B.,Kirincich, S.,Wilson, D.,Binnun, E.,Xu, W.,Joseph-McCarthy, D.,Wu, J.,Smith, M.,Zhang, Y.L.,Tam, M.,Erbe, D.,Tam, S.,Saiah, E.,Lee, J. Probing acid replacements of thiophene PTP1B inhibitors. Bioorg.Med.Chem.Lett., 17:2913-2920, 2007 Cited by PubMed: 17336064 DOI: 10.1016/j.bmcl.2007.02.043 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.1 Å)

Structure validation