2NPW

Solution Structures of a DNA Dodecamer Duplex with a Cisplatin 1,2-d(GG) Intrastrand Cross-Link

Summary for 2NPW

• Entry DOI: 10.2210/pdb2npw/pdb
• Related: 2NQ0 2NQ1 2NQ4
• Descriptor: 5'-D(*CP*CP*TP*CP*AP*GP*GP*CP*CP*TP*CP*C)-3', 5'-D(*GP*GP*AP*GP*GP*CP*CP*TP*GP*AP*GP*G)-3', Cisplatin (3 entities in total)
• Functional Keywords: deoxyribonucleic acid, cisplatin, dna, duplex, dodecamer
• Biological source: synthetic construct; More
• Total number of polymer chains: 2
• Total formula weight: 7627.82

Authors

Wu, Y.,Bhattacharyya, D.,Chaney, S.,Campbell, S. (deposition date: 2006-10-30, release date: 2007-06-12, Last modification date: 2023-12-27)

• Primary citation: Wu, Y.,Bhattacharyya, D.,King, C.L.,Baskerville-Abraham, I.,Huh, S.-H.,Boysen, G.,Swenberg, J.A.,Temple, B.,Campbell, S.L.,Chaney, S.G.; Solution Structures of a DNA Dodecamer Duplex with and without a Cisplatin 1,2-d(GG) Intrastrand Cross-Link: Comparison with the Same DNA Duplex Containing an Oxaliplatin 1,2-d(GG) Intrastrand Cross-Link; Biochemistry, 46:6477-6487, 2007; PubMed: 17497831; DOI: 10.1021/bi062291f

Experimental method

SOLUTION NMR