2NL9

Crystal structure of the Mcl-1:Bim BH3 complex

Summary for 2NL9

• Entry DOI: 10.2210/pdb2nl9/pdb
• Related: 1WSX 2NLA
• Descriptor: FUSION PROTEIN CONSISTING OF Induced myeloid leukemia cell differentiation protein Mcl-1 homolog, Bcl-2-like protein 11, ZINC ION, ... (5 entities in total)
• Functional Keywords: apoptosis, bcl-2, mcl-1, bim
• Biological source: Mus musculus (Mouse); More
• Cellular location: Membrane ; Single-pass membrane protein : Q07820; Endomembrane system ; Peripheral membrane protein . Isoform BimEL: Mitochondrion. Isoform BimL: Mitochondrion. Isoform BimS: Mitochondrion. Isoform Bim-alpha1: Mitochondrion: O43521
• Total number of polymer chains: 2
• Total formula weight: 21677.93

Authors

Czabotar, P.E.,Colman, P.M. (deposition date: 2006-10-19, release date: 2007-03-27, Last modification date: 2023-12-27)

• Primary citation: Czabotar, P.E.,Lee, E.F.,van Delft, M.F.,Day, C.L.,Smith, B.J.,Huang, D.C.,Fairlie, W.D.,Hinds, M.G.,Colman, P.M.; Structural insights into the degradation of Mcl-1 induced by BH3 domains.; Proc.Natl.Acad.Sci.USA, 104:6217-6222, 2007; PubMed: 17389404; DOI: 10.1073/pnas.0701297104

Experimental method

X-RAY DIFFRACTION (1.55 Å)