2NB6
NMR solution structure of PawS Derived Peptide 10 (PDP-10)
Summary for 2NB6
Entry DOI | 10.2210/pdb2nb6/pdb |
Related | 2NB5 |
NMR Information | BMRB: 25963 |
Descriptor | Preproalbumin PawS1 (1 entity in total) |
Functional Keywords | plant peptide, plant protein |
Biological source | Galinsoga quadriradiata (Shaggy soldier) |
Total number of polymer chains | 1 |
Total formula weight | 1817.05 |
Authors | Franke, B.G.,Elliott, A.G.,Mylne, J.S.,Rosengren, K.J. (deposition date: 2016-01-24, release date: 2016-06-29, Last modification date: 2024-11-20) |
Primary citation | Elliott, A.G.,Franke, B.,Armstrong, D.A.,Craik, D.J.,Mylne, J.S.,Rosengren, K.J. Natural structural diversity within a conserved cyclic peptide scaffold. Amino Acids, 49:103-116, 2017 Cited by PubMed Abstract: We recently isolated and described the evolutionary origin of a diverse class of small single-disulfide bonded peptides derived from Preproalbumin with SFTI-1 (PawS1) proteins in the seeds of flowering plants (Asteraceae). The founding member of the PawS derived peptide (PDP) family is the potent trypsin inhibitor SFTI-1 (sunflower trypsin inhibitor-1) from Helianthus annuus, the common sunflower. Here we provide additional structures and describe the structural diversity of this new class of small peptides, derived from solution NMR studies, in detail. We show that although most have a similar backbone framework with a single disulfide bond and in many cases a head-to-tail cyclized backbone, they all have their own characteristics in terms of projections of side-chains, flexibility and physiochemical properties, attributed to the variety of their sequences. Small cyclic and constrained peptides are popular as drug scaffolds in the pharmaceutical industry and our data highlight how amino acid side-chains can fine-tune conformations in these promising peptides. PubMed: 27695949DOI: 10.1007/s00726-016-2333-x PDB entries with the same primary citation |
Experimental method | SOLUTION NMR |
Structure validation
Download full validation report