2N96
An unexpected mode of small molecule DNA binding provides the structural basis for DNA cleavage by the potent antiproliferative agent (-)-lomaiviticin A
Summary for 2N96
Entry DOI | 10.2210/pdb2n96/pdb |
NMR Information | BMRB: 25882 |
Descriptor | DNA (5'-D(*GP*CP*TP*AP*TP*AP*GP*C)-3'), (1R,1'R,2S,2'S,3R,3'R,5aR,10aR,11a'S)-2'-[(2,6-dideoxy-3-O-methyl-alpha-L-arabino-hexopyranosyl)oxy]-2,2'-diethyl-11,11 '-dihydrazinyl-6,6',9,9'-tetrahydroxy-4,4',5,5',10,10'-hexaoxo-1,1'-bis{[2,4,6-trideoxy-4-(dimethylamino)-beta-L-arabino -hexopyranosyl]oxy}[2,2',3,3',4,4',5,5',5a,8,10,10',10a,11a'-tetradecahydro-1H,1'H-[3,3'-bibenzo[b]fluorene]]-2-yl 2,6-dideoxy-3-O-methyl-alpha-L-arabino-hexopyranoside (2 entities in total) |
Functional Keywords | diazofluorene, intercalator, dna |
Biological source | synthetic construct |
Total number of polymer chains | 2 |
Total formula weight | 6228.70 |
Authors | Woo, C.M.,Li, Z.,Paulson, E.,Herzon, S.B. (deposition date: 2015-11-07, release date: 2016-06-01, Last modification date: 2024-05-15) |
Primary citation | Woo, C.M.,Li, Z.,Paulson, E.K.,Herzon, S.B. Structural basis for DNA cleavage by the potent antiproliferative agent (-)-lomaiviticin A. Proc.Natl.Acad.Sci.USA, 113:2851-2856, 2016 Cited by PubMed: 26929332DOI: 10.1073/pnas.1519846113 PDB entries with the same primary citation |
Experimental method | SOLUTION NMR |
Structure validation
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