2N96
An unexpected mode of small molecule DNA binding provides the structural basis for DNA cleavage by the potent antiproliferative agent (-)-lomaiviticin A
2N96 の概要
エントリーDOI | 10.2210/pdb2n96/pdb |
NMR情報 | BMRB: 25882 |
分子名称 | DNA (5'-D(*GP*CP*TP*AP*TP*AP*GP*C)-3'), (1R,1'R,2S,2'S,3R,3'R,5aR,10aR,11a'S)-2'-[(2,6-dideoxy-3-O-methyl-alpha-L-arabino-hexopyranosyl)oxy]-2,2'-diethyl-11,11 '-dihydrazinyl-6,6',9,9'-tetrahydroxy-4,4',5,5',10,10'-hexaoxo-1,1'-bis{[2,4,6-trideoxy-4-(dimethylamino)-beta-L-arabino -hexopyranosyl]oxy}[2,2',3,3',4,4',5,5',5a,8,10,10',10a,11a'-tetradecahydro-1H,1'H-[3,3'-bibenzo[b]fluorene]]-2-yl 2,6-dideoxy-3-O-methyl-alpha-L-arabino-hexopyranoside (2 entities in total) |
機能のキーワード | diazofluorene, intercalator, dna |
由来する生物種 | synthetic construct |
タンパク質・核酸の鎖数 | 2 |
化学式量合計 | 6228.70 |
構造登録者 | |
主引用文献 | Woo, C.M.,Li, Z.,Paulson, E.K.,Herzon, S.B. Structural basis for DNA cleavage by the potent antiproliferative agent (-)-lomaiviticin A. Proc.Natl.Acad.Sci.USA, 113:2851-2856, 2016 Cited by PubMed: 26929332DOI: 10.1073/pnas.1519846113 主引用文献が同じPDBエントリー |
実験手法 | SOLUTION NMR |
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