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2N96

An unexpected mode of small molecule DNA binding provides the structural basis for DNA cleavage by the potent antiproliferative agent (-)-lomaiviticin A

2N96 の概要
エントリーDOI10.2210/pdb2n96/pdb
NMR情報BMRB: 25882
分子名称DNA (5'-D(*GP*CP*TP*AP*TP*AP*GP*C)-3'), (1R,1'R,2S,2'S,3R,3'R,5aR,10aR,11a'S)-2'-[(2,6-dideoxy-3-O-methyl-alpha-L-arabino-hexopyranosyl)oxy]-2,2'-diethyl-11,11 '-dihydrazinyl-6,6',9,9'-tetrahydroxy-4,4',5,5',10,10'-hexaoxo-1,1'-bis{[2,4,6-trideoxy-4-(dimethylamino)-beta-L-arabino -hexopyranosyl]oxy}[2,2',3,3',4,4',5,5',5a,8,10,10',10a,11a'-tetradecahydro-1H,1'H-[3,3'-bibenzo[b]fluorene]]-2-yl 2,6-dideoxy-3-O-methyl-alpha-L-arabino-hexopyranoside (2 entities in total)
機能のキーワードdiazofluorene, intercalator, dna
由来する生物種synthetic construct
タンパク質・核酸の鎖数2
化学式量合計6228.70
構造登録者
Woo, C.M.,Li, Z.,Paulson, E.,Herzon, S.B. (登録日: 2015-11-07, 公開日: 2016-06-01, 最終更新日: 2024-05-15)
主引用文献Woo, C.M.,Li, Z.,Paulson, E.K.,Herzon, S.B.
Structural basis for DNA cleavage by the potent antiproliferative agent (-)-lomaiviticin A.
Proc.Natl.Acad.Sci.USA, 113:2851-2856, 2016
Cited by
PubMed: 26929332
DOI: 10.1073/pnas.1519846113
主引用文献が同じPDBエントリー
実験手法
SOLUTION NMR
構造検証レポート
Validation report summary of 2n96
検証レポート(詳細版)ダウンロードをダウンロード

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件を2024-09-11に公開中

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