2N2A
Spatial structure of HER2/ErbB2 dimeric transmembrane domain in the presence of cytoplasmic juxtamembrane domains
Summary for 2N2A
| Entry DOI | 10.2210/pdb2n2a/pdb |
| NMR Information | BMRB: 25593 |
| Descriptor | Receptor tyrosine-protein kinase erbB-2 (1 entity in total) |
| Functional Keywords | her2, erbb2, tyrosine kinase, activation, transmembrane, membrane protein |
| Biological source | Homo sapiens (human) |
| Cellular location | Isoform 1: Cell membrane; Single-pass type I membrane protein. Isoform 2: Cytoplasm. Isoform 3: Cytoplasm: P04626 |
| Total number of polymer chains | 2 |
| Total formula weight | 13019.72 |
| Authors | Bragin, P.E.,Mineev, K.S.,Bocharov, E.,Bocharova, O.,Arseniev, A. (deposition date: 2015-05-05, release date: 2016-02-24, Last modification date: 2023-06-14) |
| Primary citation | Bragin, P.E.,Mineev, K.S.,Bocharova, O.V.,Volynsky, P.E.,Bocharov, E.V.,Arseniev, A.S. HER2 Transmembrane Domain Dimerization Coupled with Self-Association of Membrane-Embedded Cytoplasmic Juxtamembrane Regions. J.Mol.Biol., 428:52-61, 2016 Cited by PubMed: 26585403DOI: 10.1016/j.jmb.2015.11.007 PDB entries with the same primary citation |
| Experimental method | SOLUTION NMR |
Structure validation
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