2N26
Solution structure of Miz-1 zinc fingers 3 and 4
Summary for 2N26
| Entry DOI | 10.2210/pdb2n26/pdb |
| Related | 2N25 |
| NMR Information | BMRB: 25587 |
| Descriptor | Zinc finger and BTB domain-containing protein 17, ZINC ION (2 entities in total) |
| Functional Keywords | miz-1, zbtb17, c2h2 zinc finger, dna binding protein |
| Biological source | Homo sapiens (human) |
| Cellular location | Nucleus : Q13105 |
| Total number of polymer chains | 1 |
| Total formula weight | 12933.58 |
| Authors | Bedard, M.,Lavigne, P. (deposition date: 2015-04-28, release date: 2015-06-17, Last modification date: 2024-05-01) |
| Primary citation | Tremblay, C.,Bedard, M.,Bonin, M.A.,Lavigne, P. Solution structure of the 13th C2H2 Zinc Finger of Miz-1. Biochem.Biophys.Res.Commun., 473:471-475, 2016 Cited by PubMed Abstract: Miz-1 is a BTB/POZ transcription factor that contains 13C2H2 Zinc Finger domains (ZF). Miz-1 transactivates and represses the transcription of a myriad of genes involved in many aspects of the biology of the cell. The detailed molecular interactions through which Miz-1 controls transcription, including its specific DNA binding via its ZF domains, remain to be understood and documented. In our effort to shed light into the structural biology of Miz-1, we have undertaken the determination of the structure of all its ZF and the characterization of their interactions with cognate DNA. The structure of ZF 1 to 10 have already been solved and characterized. Here, we present the structure of the synthetic Miz-1 ZF13 determined by 2D (1)H-(1)H NMR. PubMed: 26972249DOI: 10.1016/j.bbrc.2016.03.034 PDB entries with the same primary citation |
| Experimental method | SOLUTION NMR |
Structure validation
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