2MUS
HADDOCK calculated model of LIN5001 bound to the HET-s amyloid
Summary for 2MUS
Entry DOI | 10.2210/pdb2mus/pdb |
Related | 2LBU 2RNM |
NMR Information | BMRB: 11064 |
Descriptor | Heterokaryon incompatibility protein s, 3''',4'-bis(carboxymethyl)-2,2':5',2'':5'',2''':5''',2''''-quinquethiophene-5,5''''-dicarboxylic acid (2 entities in total) |
Functional Keywords | amyloid fibril, het-s(218-289), parallel beta-sheet, beta-solenoid, prion, luminescent conjugated polythiophene, protein fibril |
Biological source | Podospora anserina (Pleurage anserina) |
Total number of polymer chains | 5 |
Total formula weight | 43955.31 |
Authors | Hermann, U.S.,Schuetz, A.K.,Shirani, H.,Saban, D.,Nuvolone, M.,Huang, D.H.,Li, B.,Ballmer, B.,Aslund, A.K.O.,Mason, J.J.,Rushing, E.,Budka, H.,Hammarstrom, P.,Bockmann, A.,Caflisch, A.,Meier, B.H.,Nilsson, P.K.R.,Hornemann, S.,Aguzzi, A. (deposition date: 2014-09-16, release date: 2017-02-01, Last modification date: 2024-05-01) |
Primary citation | Herrmann, U.S.,Schutz, A.K.,Shirani, H.,Huang, D.,Saban, D.,Nuvolone, M.,Li, B.,Ballmer, B.,Aslund, A.K.,Mason, J.J.,Rushing, E.,Budka, H.,Nystrom, S.,Hammarstrom, P.,Bockmann, A.,Caflisch, A.,Meier, B.H.,Nilsson, K.P.,Hornemann, S.,Aguzzi, A. Structure-based drug design identifies polythiophenes as antiprion compounds. Sci Transl Med, 7:299ra123-299ra123, 2015 Cited by PubMed: 26246168DOI: 10.1126/scitranslmed.aab1923 PDB entries with the same primary citation |
Experimental method | SOLUTION NMR |
Structure validation
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