2MU8
Residues belonging the n-terminal region derived of merozoite surface protein-2 of plasmodium falciparum
Summary for 2MU8
Entry DOI | 10.2210/pdb2mu8/pdb |
Related | 2MU7 |
NMR Information | BMRB: 25202 |
Descriptor | MSP-2 peptide (1 entity in total) |
Functional Keywords | merozoite surface protein 2, classic beta-turn, cell invasion |
Biological source | Plasmodium falciparum |
Total number of polymer chains | 1 |
Total formula weight | 2397.64 |
Authors | Cifuentes, G.,Patarroyo, M.E.,Urquiza, M.,Ramirez, L.E.,Reyes, C.,Rodriguez, R. (deposition date: 2014-09-04, release date: 2014-11-12, Last modification date: 2024-05-15) |
Primary citation | Cifuentes, G.,Patarroyo, M.E.,Urquiza, M.,Ramirez, L.E.,Reyes, C.,Rodriguez, R. Distorting malaria peptide backbone structure to enable fitting into MHC class II molecules renders modified peptides immunogenic and protective. J.Med.Chem., 46:2250-2253, 2003 Cited by PubMed Abstract: The conserved, nonantigenic, nonimmunogenic malaria Merozoite Surface Protein-2 peptide 1, having high affinity for red blood cells, was rendered immunogenic and protective in Aotus monkeys by specifically changing some critical residues. The NMR structure revealed a switch from classical type III' into distorted III' and III beta turns in the protective peptides. These changes may lead to a better fit into the Aotus MHC class II human HLA-DRbeta1 12 molecule equivalent, thus activating the immune system. PubMed: 12747797DOI: 10.1021/jm020440w PDB entries with the same primary citation |
Experimental method | SOLUTION NMR |
Structure validation
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