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2MU8

Residues belonging the n-terminal region derived of merozoite surface protein-2 of plasmodium falciparum

Summary for 2MU8
Entry DOI10.2210/pdb2mu8/pdb
Related2MU7
NMR InformationBMRB: 25202
DescriptorMSP-2 peptide (1 entity in total)
Functional Keywordsmerozoite surface protein 2, classic beta-turn, cell invasion
Biological sourcePlasmodium falciparum
Total number of polymer chains1
Total formula weight2397.64
Authors
Cifuentes, G.,Patarroyo, M.E.,Urquiza, M.,Ramirez, L.E.,Reyes, C.,Rodriguez, R. (deposition date: 2014-09-04, release date: 2014-11-12, Last modification date: 2024-05-15)
Primary citationCifuentes, G.,Patarroyo, M.E.,Urquiza, M.,Ramirez, L.E.,Reyes, C.,Rodriguez, R.
Distorting malaria peptide backbone structure to enable fitting into MHC class II molecules renders modified peptides immunogenic and protective.
J.Med.Chem., 46:2250-2253, 2003
Cited by
PubMed Abstract: The conserved, nonantigenic, nonimmunogenic malaria Merozoite Surface Protein-2 peptide 1, having high affinity for red blood cells, was rendered immunogenic and protective in Aotus monkeys by specifically changing some critical residues. The NMR structure revealed a switch from classical type III' into distorted III' and III beta turns in the protective peptides. These changes may lead to a better fit into the Aotus MHC class II human HLA-DRbeta1 12 molecule equivalent, thus activating the immune system.
PubMed: 12747797
DOI: 10.1021/jm020440w
PDB entries with the same primary citation
Experimental method
SOLUTION NMR
Structure validation

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