2MQU

Spatial structure of Hm-3, a membrane-active spider toxin affecting sodium channels

Summary for 2MQU

DescriptorNeurotoxin Hm-3 (1 entity in total)
Functional Keywordsspider toxins, voltage-gated sodium channels, gating modifiers, inhibitor cystine knot, ick, channel activation, toxin
Biological sourceHeriaeus melloteei (Crab spider)
Total number of polymer chains1
Total molecular weight3919.71
Authors
Myshkin, M.Y.,Shenkarev, Z.O.,Paramonov, A.S.,Berkut, A.A.,Grishin, E.V.,Vassilevski, A.A. (deposition date: 2014-06-27, release date: 2014-11-05, Last modification date: 2019-02-20)
Primary citation
Berkut, A.A.,Peigneur, S.,Myshkin, M.Y.,Paramonov, A.S.,Lyukmanova, E.N.,Arseniev, A.S.,Grishin, E.V.,Tytgat, J.,Shenkarev, Z.O.,Vassilevski, A.A.
Structure of membrane-active toxin from crab spider Heriaeus melloteei suggests parallel evolution of sodium channel gating modifiers in Araneomorphae and Mygalomorphae.
J. Biol. Chem., 290:492-504, 2015
PubMed: 25352595 (PDB entries with the same primary citation)
DOI: 10.1074/jbc.M114.595678
MImport into Mendeley
Experimental method
SOLUTION NMR
NMR Information
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Structure validation

ClashscoreRamachandran outliersSidechain outliers12 3.0% 14.1%MetricValuePercentile RanksWorseBetterPercentile relative to all structuresPercentile relative to all NMR structures

More Asymmetric unit images

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