2MPG

Solution structure of the [AibB8,LysB28,ProB29]-insulin analogue

Summary for 2MPG

• Entry DOI: 10.2210/pdb2mpg/pdb
• NMR Information: BMRB: 19978
• Descriptor: Insulin A chain, Insulin B chain (2 entities in total)
• Functional Keywords: insulin analogue, hormone
• Biological source: Homo sapiens (human); More
• Cellular location: Secreted: P01308 P01308
• Total number of polymer chains: 2
• Total formula weight: 5845.70

Authors

Kosinova, L.,Jiracek, J.,Zakova, L.,Veverka, V. (deposition date: 2014-05-17, release date: 2014-06-11, Last modification date: 2023-12-27)

• Primary citation: Kosinova, L.,Veverka, V.,Novotna, P.,Collinsova, M.,Urbanova, M.,Moody, N.R.,Turkenburg, J.P.,Jiracek, J.,Brzozowski, A.M.,Zakova, L.; Insight into the structural and biological relevance of the T/R transition of the N-terminus of the B-chain in human insulin.; Biochemistry, 53:3392-3402, 2014; PubMed: 24819248; DOI: 10.1021/bi500073z

Experimental method

SOLUTION NMR